Transcription factors with Perturb-seq knockdown data for CARHSP1-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CARHSP1-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CARHSP1-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:8,863,607–8,864,055 | 5.2 kb | Proximal (<10kb) | 680 | |
| chr16:8,866,241–8,867,974 | 1.3 kb | Proximal (<10kb) | 680 | |
| chr16:8,868,171–8,869,530 | at TSS | At TSS | 934 | |
| chr16:8,869,586–8,869,916 | 336 bp | At TSS | 354 |
Genomic view of the CARHSP1-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.