Calcyphosine-2 is a calcium-binding protein with 2 EF-hand motifs (Wang et al., 2002 [PubMed 11846421]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for CAPS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAPS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAPS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:75,329,660–75,330,647 | 60.7 kb | Distal (>10kb) Multiome | 840 | |
| chr12:75,333,989–75,335,193 | 56.4 kb | Distal (>10kb) Multiome | 460 | |
| chr12:75,390,488–75,391,621 | 210 bp | At TSS Multiome | 653 | |
| chr12:75,484,124–75,485,111 | 93.7 kb | Distal (>10kb) Multiome | 121 | |
| chr12:75,511,106–75,512,100 | 120.8 kb | Distal (>10kb) Multiome | 945 |
Genomic view of the CAPS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.