The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CAMKK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAMKK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAMKK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:3,635,650–3,637,225 | 256.6 kb | Distal (>10kb) Multiome | 866 | |
| chr17:3,667,393–3,669,475 | 224.4 kb | Distal (>10kb) Multiome | 949 | |
| chr17:3,723,432–3,724,429 | 169.2 kb | Distal (>10kb) Multiome | 865 | |
| chr17:3,754,197–3,755,835 | 138.2 kb | Distal (>10kb) Multiome | 396 | |
| chr17:3,845,518–3,846,549 | 46.8 kb | Distal (>10kb) Multiome | 917 | |
| chr17:3,891,925–3,893,745 | 213 bp | At TSS Multiome | 716 | |
| chr17:3,944,497–3,945,384 | 51.8 kb | Distal (>10kb) Multiome | 277 | |
| chr17:3,964,969–3,965,418 | 72.2 kb | Distal (>10kb) Multiome | 333 | |
| chr17:4,003,950–4,004,421 | 110.9 kb | Distal (>10kb) Multiome | 404 | |
| chr17:4,004,672–4,005,109 | 111.8 kb | Distal (>10kb) Multiome | 632 | |
| chr17:4,142,469–4,144,218 | 250.8 kb | Distal (>10kb) Multiome | 1007 |
Genomic view of the CAMKK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.