Enables myosin head/neck binding activity. Involved in brush border assembly. Located in microvillus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CALML4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CALML4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CALML4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:67,839,939–67,840,842 | 365.8 kb | Distal (>10kb) Multiome HiCAR | 902 | |
| chr15:67,863,421–67,864,037 | 342.4 kb | Distal (>10kb) Multiome HiCAR | 767 | |
| chr15:67,967,988–67,968,440 | 237.8 kb | Distal (>10kb) Multiome | 234 | |
| chr15:68,053,850–68,055,256 | 151.8 kb | Distal (>10kb) Multiome | 832 | |
| chr15:68,206,060–68,206,347 | at TSS | At TSS | 185 | |
| chr15:68,210,886–68,211,122 | 4.8 kb | Proximal (<10kb) | 239 | |
| chr15:68,229,045–68,230,269 | 23.6 kb | Distal (>10kb) Multiome | 889 | |
| chr15:68,256,694–68,257,399 | 51.1 kb | Distal (>10kb) Multiome | 551 | |
| chr15:68,277,201–68,278,718 | 71.8 kb | Distal (>10kb) Multiome | 1100 | |
| chr15:68,431,141–68,432,391 | 226.1 kb | Distal (>10kb) Multiome | 295 |
Genomic view of the CALML4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.