The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for CACNG5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CACNG5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CACNG5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:66,730,366–66,730,876 | 104.4 kb | Distal (>10kb) Multiome | 163 | |
| chr17:66,777,458–66,778,215 | 57.3 kb | Distal (>10kb) Multiome | 191 | |
| chr17:66,829,608–66,829,834 | 5.3 kb | Proximal (<10kb) | 289 | |
| chr17:66,830,465–66,830,760 | 4.4 kb | Proximal (<10kb) | 50 | |
| chr17:66,834,798–66,835,510 | 12 bp | At TSS Multiome | 194 | |
| chr17:66,964,279–66,965,391 | 129.4 kb | Distal (>10kb) Multiome | 284 | |
| chr17:66,965,500–66,966,143 | 130.6 kb | Distal (>10kb) Multiome | 221 |
Genomic view of the CACNG5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.