This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for CACNB3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CACNB3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CACNB3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:48,681,532–48,682,844 | 133.3 kb | Distal (>10kb) Multiome | 933 | |
| chr12:48,716,299–48,717,435 | 98.7 kb | Distal (>10kb) Multiome | 1077 | |
| chr12:48,788,600–48,789,901 | 26.3 kb | Distal (>10kb) Multiome | 478 | |
| chr12:48,795,703–48,796,330 | 19.6 kb | Distal (>10kb) Multiome | 333 | |
| chr12:48,814,087–48,815,981 | 791 bp | At TSS Multiome | 815 | |
| chr12:48,817,927–48,819,273 | 3.0 kb | Proximal (<10kb) Multiome | 459 | |
| chr12:48,851,862–48,852,825 | 36.6 kb | Distal (>10kb) Multiome | 900 | |
| chr12:48,864,974–48,866,292 | 50.3 kb | Distal (>10kb) Multiome | 649 | |
| chr12:48,883,231–48,884,168 | 68.2 kb | Distal (>10kb) Multiome | 433 | |
| chr12:48,890,671–48,891,380 | 75.4 kb | Distal (>10kb) Multiome | 517 | |
| chr12:48,924,659–48,925,688 | 109.3 kb | Distal (>10kb) Multiome | 413 | |
| chr12:48,956,252–48,957,974 | 140.9 kb | Distal (>10kb) Multiome | 831 | |
| chr12:48,978,055–48,978,819 | 162.7 kb | Distal (>10kb) Multiome | 360 | |
| chr12:48,980,647–48,981,153 | 165.3 kb | Distal (>10kb) Multiome | 259 | |
| chr12:48,997,612–48,998,829 | 182.7 kb | Distal (>10kb) Multiome | 620 | |
| chr12:49,018,007–49,019,184 | 203.1 kb | Distal (>10kb) Multiome | 899 | |
| chr12:49,059,883–49,061,347 | 245.2 kb | Distal (>10kb) Multiome | 1060 | |
| chr12:49,069,381–49,070,589 | 254.4 kb | Distal (>10kb) Multiome | 804 | |
| chr12:49,088,153–49,088,744 | 272.9 kb | Distal (>10kb) Multiome | 473 | |
| chr12:49,109,990–49,111,248 | 295.3 kb | Distal (>10kb) Multiome | 693 |
Genomic view of the CACNB3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.