The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CACNB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CACNB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CACNB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:38,967,321–38,967,861 | 230.1 kb | Distal (>10kb) Multiome | 219 | |
| chr17:39,056,695–39,057,296 | 140.7 kb | Distal (>10kb) Multiome | 468 | |
| chr17:39,152,575–39,154,848 | 44.7 kb | Distal (>10kb) Multiome | 1041 | |
| chr17:39,164,617–39,165,311 | 32.8 kb | Distal (>10kb) Multiome | 371 | |
| chr17:39,197,170–39,198,193 | 43 bp | At TSS Multiome | 515 | |
| chr17:39,199,726–39,200,760 | 2.5 kb | Proximal (<10kb) Multiome | 947 | |
| chr17:39,209,452–39,209,995 | 12.2 kb | Distal (>10kb) Multiome | 268 | |
| chr17:39,225,532–39,226,262 | 28.3 kb | Distal (>10kb) Multiome | 235 | |
| chr17:39,244,638–39,245,241 | 47.2 kb | Distal (>10kb) Multiome | 348 | |
| chr17:39,400,997–39,402,766 | 204.0 kb | Distal (>10kb) Multiome | 898 | |
| chr17:39,450,919–39,451,504 | 253.7 kb | Distal (>10kb) Multiome | 722 | |
| chr17:39,461,043–39,462,217 | 263.8 kb | Distal (>10kb) Multiome | 1026 |
Genomic view of the CACNB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.