Enables hormone activity. Involved in negative regulation of cholesterol biosynthetic process. Is active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C7orf50. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C7orf50 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C7orf50, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:875,946–877,507 | 261.7 kb | Distal (>10kb) Multiome | 918 | |
| chr7:901,112–902,113 | 236.6 kb | Distal (>10kb) Multiome | 376 | |
| chr7:953,606–955,017 | 183.7 kb | Distal (>10kb) Multiome | 482 | |
| chr7:974,909–975,889 | 162.7 kb | Distal (>10kb) Multiome | 860 | |
| chr7:992,812–993,637 | 144.9 kb | Distal (>10kb) Multiome | 824 | |
| chr7:1,028,063–1,028,589 | 109.9 kb | Distal (>10kb) Multiome | 503 | |
| chr7:1,044,102–1,045,027 | 93.8 kb | Distal (>10kb) Multiome | 715 | |
| chr7:1,059,302–1,060,226 | 78.5 kb | Distal (>10kb) Multiome | 156 | |
| chr7:1,137,933–1,138,672 | 68 bp | At TSS Multiome | 673 | |
| chr7:1,141,796–1,142,263 | 3.5 kb | Proximal (<10kb) | 39 | |
| chr7:1,159,935–1,160,583 | 22.1 kb | Distal (>10kb) Multiome | 746 | |
| chr7:1,235,892–1,237,020 | 98.2 kb | Distal (>10kb) Multiome | 184 | |
| chr7:1,368,617–1,369,820 | 231.0 kb | Distal (>10kb) Multiome | 421 | |
| chr7:1,412,524–1,413,381 | 274.7 kb | Distal (>10kb) Multiome | 526 |
Genomic view of the C7orf50 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.