Involved in several processes, including chromatin remodeling; epithelial cell proliferation; and wound healing. Located in several cellular components, including Golgi membrane; midbody; and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C6orf89. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C6orf89 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C6orf89, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:36,593,473–36,594,773 | 291.7 kb | Distal (>10kb) Multiome | 1156 | |
| chr6:36,650,865–36,651,585 | 234.8 kb | Distal (>10kb) Multiome | 207 | |
| chr6:36,678,325–36,679,788 | 207.3 kb | Distal (>10kb) Multiome | 955 | |
| chr6:36,863,795–36,864,608 | 21.8 kb | Distal (>10kb) Multiome | 173 | |
| chr6:36,874,493–36,875,198 | 11.1 kb | Distal (>10kb) Multiome | 1007 | |
| chr6:36,885,507–36,886,260 | 67 bp | At TSS Multiome | 1011 | |
| chr6:36,985,740–36,986,913 | 100.4 kb | Distal (>10kb) Multiome | 926 | |
| chr6:37,051,534–37,052,487 | 165.8 kb | Distal (>10kb) Multiome | 766 | |
| chr6:37,059,338–37,060,100 | 173.7 kb | Distal (>10kb) Multiome | 824 | |
| chr6:37,071,640–37,072,385 | 185.9 kb | Distal (>10kb) Multiome | 281 | |
| chr6:37,102,284–37,103,074 | 216.7 kb | Distal (>10kb) Multiome | 855 | |
| chr6:37,125,557–37,126,783 | 240.1 kb | Distal (>10kb) Multiome | 528 | |
| chr6:37,137,028–37,138,409 | 251.8 kb | Distal (>10kb) Multiome | 735 | |
| chr6:37,141,368–37,141,988 | 255.8 kb | Distal (>10kb) Multiome | 239 | |
| chr6:37,168,853–37,171,673 | 284.0 kb | Distal (>10kb) Multiome | 1096 | |
| chr6:37,172,048–37,172,496 | 286.4 kb | Distal (>10kb) Multiome | 818 |
Genomic view of the C6orf89 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.