Transcription factors with Perturb-seq knockdown data for C2orf76. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C2orf76 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C2orf76, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:119,155,495–119,157,277 | 210.9 kb | Distal (>10kb) Multiome | 202 | |
| chr2:119,218,121–119,219,066 | 148.1 kb | Distal (>10kb) Multiome | 361 | |
| chr2:119,223,024–119,224,452 | 143.0 kb | Distal (>10kb) Multiome | 761 | |
| chr2:119,366,351–119,367,938 | 97 bp | At TSS Multiome | 994 | |
| chr2:119,431,298–119,432,803 | 64.9 kb | Distal (>10kb) Multiome | 903 | |
| chr2:119,476,117–119,476,795 | 109.7 kb | Distal (>10kb) Multiome | 482 | |
| chr2:119,523,786–119,524,663 | 157.5 kb | Distal (>10kb) Multiome | 187 | |
| chr2:119,537,405–119,538,283 | 171.0 kb | Distal (>10kb) Multiome | 122 | |
| chr2:119,544,074–119,545,082 | 177.6 kb | Distal (>10kb) Multiome | 610 |
Genomic view of the C2orf76 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.