Transcription factors with Perturb-seq knockdown data for C2orf27A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C2orf27A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C2orf27A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:131,153,640–131,154,672 | 528.3 kb | Distal (>10kb) Multiome HiCAR | 397 | |
| chr2:131,492,005–131,493,530 | 189.6 kb | Distal (>10kb) Multiome | 829 | |
| chr2:131,527,544–131,528,836 | 154.6 kb | Distal (>10kb) Multiome | 152 | |
| chr2:131,672,051–131,674,269 | 9.7 kb | Proximal (<10kb) Multiome | 465 | |
| chr2:131,681,926–131,683,271 | 15 bp | At TSS Multiome | 661 | |
| chr2:131,801,441–131,803,072 | 120.2 kb | Distal (>10kb) Multiome | 292 |
Genomic view of the C2orf27A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.