Transcription factors with Perturb-seq knockdown data for C2CD4D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C2CD4D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C2CD4D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:151,830,720–151,831,056 | 8.8 kb | Proximal (<10kb) | 324 | |
| chr1:151,836,313–151,836,752 | 3.1 kb | Proximal (<10kb) | 359 | |
| chr1:151,837,933–151,839,171 | 648 bp | At TSS | 219 | |
| chr1:151,839,238–151,840,386 | at TSS | At TSS | 493 |
Genomic view of the C2CD4D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.