Predicted to be involved in negative regulation of long-term synaptic potentiation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C22orf39. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C22orf39 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C22orf39, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:19,149,463–19,150,252 | 298.1 kb | Distal (>10kb) Multiome | 173 | |
| chr22:19,169,265–19,169,982 | 278.0 kb | Distal (>10kb) Multiome | 285 | |
| chr22:19,170,964–19,172,196 | 276.1 kb | Distal (>10kb) Multiome | 819 | |
| chr22:19,177,562–19,180,087 | 268.9 kb | Distal (>10kb) Multiome | 875 | |
| chr22:19,290,875–19,292,389 | 155.9 kb | Distal (>10kb) Multiome | 854 | |
| chr22:19,431,488–19,432,799 | 15.3 kb | Distal (>10kb) Multiome | 1140 | |
| chr22:19,446,962–19,448,379 | 42 bp | At TSS Multiome | 889 | |
| chr22:19,478,898–19,480,311 | 32.0 kb | Distal (>10kb) Multiome | 867 | |
| chr22:19,523,289–19,524,793 | 75.9 kb | Distal (>10kb) Multiome | 242 | |
| chr22:19,717,840–19,718,731 | 270.5 kb | Distal (>10kb) Multiome | 592 | |
| chr22:19,723,413–19,724,584 | 276.5 kb | Distal (>10kb) Multiome | 572 | |
| chr22:19,730,516–19,731,296 | 283.2 kb | Distal (>10kb) Multiome | 743 |
Genomic view of the C22orf39 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.