Transcription factors with Perturb-seq knockdown data for C22orf15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C22orf15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C22orf15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:23,766,697–23,767,161 | 3.7 kb | Proximal (<10kb) | 335 | |
| chr22:23,767,199–23,768,799 | 4.2 kb | Proximal (<10kb) | 812 | |
| chr22:23,771,024–23,771,248 | 8.0 kb | Proximal (<10kb) | 159 | |
| chr22:23,772,486–23,773,491 | 9.5 kb | Proximal (<10kb) | 415 |
Genomic view of the C22orf15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.