Transcription factors with Perturb-seq knockdown data for C20orf204. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C20orf204 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C20orf204, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:64,030,226–64,031,221 | 5.0 kb | Proximal (<10kb) | 159 | |
| chr20:64,035,822–64,036,230 | at TSS | At TSS | 537 | |
| chr20:64,037,552–64,038,223 | 1.4 kb | Proximal (<10kb) | 265 | |
| chr20:64,038,338–64,039,469 | 2.2 kb | Proximal (<10kb) | 628 | |
| chr20:64,047,989–64,049,987 | 9.9 kb | Proximal (<10kb) | 541 |
Genomic view of the C20orf204 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.