Enables RNA binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C1orf52. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C1orf52 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C1orf52, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:84,944,592–84,945,445 | 314.7 kb | Distal (>10kb) Multiome HiCAR | 438 | |
| chr1:84,996,442–84,998,604 | 262.5 kb | Distal (>10kb) Multiome | 490 | |
| chr1:85,047,243–85,049,064 | 211.4 kb | Distal (>10kb) Multiome | 533 | |
| chr1:85,061,692–85,062,785 | 197.4 kb | Distal (>10kb) Multiome HiCAR | 384 | |
| chr1:85,200,160–85,202,231 | 58.6 kb | Distal (>10kb) Multiome | 895 | |
| chr1:85,224,822–85,225,910 | 34.4 kb | Distal (>10kb) Multiome | 499 | |
| chr1:85,254,395–85,254,722 | 4.9 kb | Proximal (<10kb) | 11 | |
| chr1:85,254,863–85,254,995 | 4.7 kb | Proximal (<10kb) | 83 | |
| chr1:85,258,924–85,260,262 | 25 bp | At TSS Multiome | 782 | |
| chr1:85,275,751–85,277,437 | 17.0 kb | Distal (>10kb) Multiome | 868 | |
| chr1:85,307,937–85,308,862 | 48.6 kb | Distal (>10kb) Multiome | 554 | |
| chr1:85,464,074–85,465,652 | 205.4 kb | Distal (>10kb) Multiome | 747 |
Genomic view of the C1orf52 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.