Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C1orf174. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C1orf174 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C1orf174, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:3,610,667–3,612,281 | 288.6 kb | Distal (>10kb) Multiome | 361 | |
| chr1:3,624,289–3,625,883 | 275.4 kb | Distal (>10kb) Multiome | 814 | |
| chr1:3,649,785–3,650,304 | 250.2 kb | Distal (>10kb) Multiome | 620 | |
| chr1:3,651,921–3,653,136 | 247.5 kb | Distal (>10kb) Multiome | 369 | |
| chr1:3,746,744–3,747,607 | 152.9 kb | Distal (>10kb) Multiome | 523 | |
| chr1:3,771,515–3,773,363 | 127.7 kb | Distal (>10kb) Multiome | 733 | |
| chr1:3,793,373–3,793,897 | 106.6 kb | Distal (>10kb) Multiome | 182 | |
| chr1:3,795,866–3,796,907 | 103.7 kb | Distal (>10kb) Multiome | 835 | |
| chr1:3,856,527–3,858,218 | 42.9 kb | Distal (>10kb) Multiome | 815 | |
| chr1:3,899,608–3,901,755 | 1.2 kb | Proximal (<10kb) Multiome | 1026 | |
| chr1:3,910,694–3,911,367 | 10.8 kb | Distal (>10kb) Multiome | 321 | |
| chr1:4,653,855–4,656,775 | 756.2 kb | Distal (>10kb) Multiome HiCAR | 236 | |
| chr1:4,660,986–4,661,543 | 761.0 kb | Distal (>10kb) Multiome HiCAR | 123 | |
| chr1:4,710,737–4,711,736 | 810.9 kb | Distal (>10kb) Multiome HiCAR | 293 | |
| chr1:5,129,790–5,130,404 | 1229.8 kb | Distal (>10kb) Multiome HiCAR | 12 | |
| chr1:5,225,357–5,227,093 | 1326.2 kb | Distal (>10kb) Multiome HiCAR | 289 | |
| chr1:5,771,235–5,771,777 | 1871.2 kb | Distal (>10kb) Multiome HiCAR | 90 |
Genomic view of the C1orf174 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.