Predicted to enable identical protein binding activity. Predicted to act upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of fat cell differentiation; and negative regulation of fibroblast proliferation. Predicted to be located in extracellular space. Predicted to be part of collagen trimer. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C1QL4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C1QL4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C1QL4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:49,331,725–49,331,898 | 5.3 kb | Proximal (<10kb) | 233 | |
| chr12:49,336,785–49,337,369 | at TSS | At TSS | 482 | |
| chr12:49,341,800–49,343,265 | 4.6 kb | Proximal (<10kb) | 631 | |
| chr12:49,345,164–49,345,657 | 8.0 kb | Proximal (<10kb) | 182 | |
| chr12:49,346,647–49,347,021 | 9.5 kb | Proximal (<10kb) | 348 | |
| chr12:49,347,124–49,348,156 | 9.9 kb | Proximal (<10kb) | 790 |
Genomic view of the C1QL4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.