Transcription factors with Perturb-seq knockdown data for C19orf73. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C19orf73 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C19orf73, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:49,113,727–49,115,240 | 3.9 kb | Proximal (<10kb) | 746 | |
| chr19:49,118,477–49,120,300 | at TSS | At TSS | 949 | |
| chr19:49,125,412–49,125,791 | 6.3 kb | Proximal (<10kb) | 267 | |
| chr19:49,127,647–49,128,949 | 8.5 kb | Proximal (<10kb) | 1000 | |
| chr19:49,129,106–49,129,678 | 10.0 kb | Proximal (<10kb) | 197 |
Genomic view of the C19orf73 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.