Transcription factors with Perturb-seq knockdown data for C19orf44. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C19orf44 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C19orf44, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:14,979,199–14,980,219 | 1516.6 kb | Distal (>10kb) Multiome HiCAR | 147 | |
| chr19:15,378,833–15,380,802 | 1116.5 kb | Distal (>10kb) Multiome HiCAR | 913 | |
| chr19:16,197,472–16,198,501 | 298.5 kb | Distal (>10kb) Multiome | 806 | |
| chr19:16,247,463–16,247,928 | 248.6 kb | Distal (>10kb) Multiome | 370 | |
| chr19:16,324,466–16,326,401 | 170.3 kb | Distal (>10kb) Multiome | 477 | |
| chr19:16,471,332–16,472,638 | 24.3 kb | Distal (>10kb) Multiome | 645 | |
| chr19:16,495,870–16,496,694 | 112 bp | At TSS Multiome | 780 | |
| chr19:16,541,995–16,543,080 | 46.1 kb | Distal (>10kb) Multiome | 880 | |
| chr19:16,571,833–16,572,764 | 76.1 kb | Distal (>10kb) Multiome | 814 | |
| chr19:16,627,176–16,629,209 | 132.0 kb | Distal (>10kb) Multiome | 896 | |
| chr19:16,659,555–16,661,823 | 163.7 kb | Distal (>10kb) Multiome | 987 |
Genomic view of the C19orf44 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.