Transcription factors with Perturb-seq knockdown data for C17orf107. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C17orf107 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C17orf107, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:4,898,962–4,900,112 | at TSS | At TSS | 257 | |
| chr17:4,900,249–4,901,057 | 832 bp | At TSS | 145 | |
| chr17:4,903,636–4,903,840 | 4.2 kb | Proximal (<10kb) | 228 | |
| chr17:4,909,117–4,909,538 | 9.7 kb | Proximal (<10kb) | 553 |
Genomic view of the C17orf107 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.