Enables RNA binding activity. Predicted to act upstream of or within cell differentiation and positive regulation of gene expression. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C14orf93. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C14orf93 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C14orf93, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:22,766,419–22,767,375 | 240.4 kb | Distal (>10kb) Multiome | 988 | |
| chr14:22,821,826–22,823,530 | 184.2 kb | Distal (>10kb) Multiome | 649 | |
| chr14:22,829,704–22,830,328 | 177.2 kb | Distal (>10kb) Multiome | 871 | |
| chr14:22,836,107–22,837,017 | 170.7 kb | Distal (>10kb) Multiome | 320 | |
| chr14:22,852,845–22,853,709 | 153.8 kb | Distal (>10kb) Multiome | 788 | |
| chr14:22,870,967–22,873,202 | 135.5 kb | Distal (>10kb) Multiome | 1167 | |
| chr14:22,882,594–22,883,886 | 123.9 kb | Distal (>10kb) Multiome | 289 | |
| chr14:22,886,371–22,887,824 | 119.9 kb | Distal (>10kb) Multiome | 639 | |
| chr14:22,918,527–22,919,975 | 87.8 kb | Distal (>10kb) Multiome | 641 | |
| chr14:22,928,961–22,930,849 | 77.6 kb | Distal (>10kb) Multiome | 1108 | |
| chr14:22,956,530–22,957,512 | 50.1 kb | Distal (>10kb) Multiome | 983 | |
| chr14:22,981,215–22,983,249 | 24.4 kb | Distal (>10kb) Multiome | 935 | |
| chr14:23,006,674–23,007,583 | 44 bp | At TSS Multiome | 1097 | |
| chr14:23,010,090–23,010,488 | 3.0 kb | Proximal (<10kb) | 650 | |
| chr14:23,020,642–23,021,291 | 13.8 kb | Distal (>10kb) Multiome | 148 | |
| chr14:23,101,326–23,101,861 | 94.5 kb | Distal (>10kb) Multiome | 83 | |
| chr14:23,154,159–23,154,639 | 147.3 kb | Distal (>10kb) Multiome | 392 | |
| chr14:23,161,040–23,161,530 | 154.2 kb | Distal (>10kb) Multiome | 397 | |
| chr14:23,182,495–23,182,942 | 175.6 kb | Distal (>10kb) Multiome | 139 | |
| chr14:23,237,732–23,238,192 | 230.8 kb | Distal (>10kb) Multiome | 536 | |
| chr14:23,285,641–23,286,830 | 279.1 kb | Distal (>10kb) Multiome | 962 | |
| chr14:23,300,944–23,303,002 | 294.6 kb | Distal (>10kb) Multiome | 1096 | |
| chr14:23,306,324–23,307,321 | 299.7 kb | Distal (>10kb) Multiome | 871 |
Genomic view of the C14orf93 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.