Involved in homologous chromosome pairing at meiosis. Predicted to be located in chromosome. Predicted to be active in central element. Implicated in primary ovarian insufficiency 18 and spermatogenic failure 52. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C14orf39. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C14orf39 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C14orf39, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:60,247,765–60,250,615 | 236.9 kb | Distal (>10kb) Multiome | 1091 | |
| chr14:60,331,221–60,332,142 | 154.3 kb | Distal (>10kb) Multiome | 515 | |
| chr14:60,485,178–60,486,252 | 94 bp | At TSS Multiome | 378 | |
| chr14:60,508,535–60,510,247 | 23.0 kb | Distal (>10kb) Multiome | 245 | |
| chr14:60,514,579–60,516,786 | 28.9 kb | Distal (>10kb) Multiome | 517 | |
| chr14:60,637,200–60,638,337 | 151.8 kb | Distal (>10kb) Multiome | 201 | |
| chr14:60,641,851–60,643,218 | 156.4 kb | Distal (>10kb) Multiome | 222 | |
| chr14:60,648,454–60,651,189 | 164.8 kb | Distal (>10kb) Multiome | 790 | |
| chr14:60,655,802–60,657,953 | 171.2 kb | Distal (>10kb) Multiome | 631 | |
| chr14:60,720,299–60,724,768 | 238.3 kb | Distal (>10kb) Multiome | 933 |
Genomic view of the C14orf39 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.