Transcription factors with Perturb-seq knockdown data for C11orf91. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C11orf91 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C11orf91, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:33,691,147–33,691,394 | 9.4 kb | Proximal (<10kb) | 279 | |
| chr11:33,692,903–33,693,491 | 7.3 kb | Proximal (<10kb) | 35 | |
| chr11:33,698,163–33,698,639 | 2.2 kb | Proximal (<10kb) | 28 | |
| chr11:33,699,853–33,701,513 | at TSS | At TSS | 711 | |
| chr11:33,704,365–33,704,606 | 3.5 kb | Proximal (<10kb) | 50 |
Genomic view of the C11orf91 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.