Transcription factors with Perturb-seq knockdown data for C10orf95. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C10orf95 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C10orf95, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:102,449,444–102,451,250 | 292 bp | At TSS | 810 | |
| chr10:102,453,103–102,453,526 | 1.6 kb | Proximal (<10kb) | 232 | |
| chr10:102,454,792–102,455,588 | 3.2 kb | Proximal (<10kb) | 159 | |
| chr10:102,455,906–102,456,180 | 4.4 kb | Proximal (<10kb) | 294 | |
| chr10:102,460,805–102,462,064 | 9.3 kb | Proximal (<10kb) | 665 |
Genomic view of the C10orf95 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.