Enables nuclear receptor binding activity and transcription coactivator activity. Involved in mRNA splicing, via spliceosome. Located in centrosome; chromatin; and nucleoplasm. Part of U2-type catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BUD31. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BUD31 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BUD31, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:99,142,006–99,144,629 | 266.6 kb | Distal (>10kb) Multiome | 865 | |
| chr7:99,325,304–99,326,401 | 83.1 kb | Distal (>10kb) Multiome | 858 | |
| chr7:99,373,955–99,375,619 | 33.4 kb | Distal (>10kb) Multiome | 759 | |
| chr7:99,392,361–99,394,025 | 15.8 kb | Distal (>10kb) Multiome | 486 | |
| chr7:99,407,975–99,409,432 | 158 bp | At TSS Multiome | 975 | |
| chr7:99,415,618–99,415,785 | 6.7 kb | Proximal (<10kb) | 50 | |
| chr7:99,438,371–99,439,668 | 30.1 kb | Distal (>10kb) Multiome | 881 | |
| chr7:99,465,842–99,466,381 | 57.2 kb | Distal (>10kb) Multiome | 949 | |
| chr7:99,471,690–99,473,325 | 63.8 kb | Distal (>10kb) Multiome | 861 | |
| chr7:99,499,759–99,500,629 | 91.3 kb | Distal (>10kb) Multiome | 809 | |
| chr7:99,504,224–99,505,507 | 95.8 kb | Distal (>10kb) Multiome | 881 | |
| chr7:99,557,927–99,559,319 | 149.7 kb | Distal (>10kb) Multiome | 922 | |
| chr7:99,580,108–99,580,792 | 171.4 kb | Distal (>10kb) Multiome | 296 | |
| chr7:99,616,474–99,617,353 | 207.9 kb | Distal (>10kb) Multiome | 1043 | |
| chr7:99,693,257–99,693,867 | 284.6 kb | Distal (>10kb) Multiome | 518 |
Genomic view of the BUD31 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.