The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Transcription factors with Perturb-seq knockdown data for BTG3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BTG3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BTG3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:17,436,486–17,437,621 | 175.9 kb | Distal (>10kb) Multiome | 197 | |
| chr21:17,454,250–17,455,351 | 158.1 kb | Distal (>10kb) Multiome | 838 | |
| chr21:17,492,445–17,493,147 | 120.2 kb | Distal (>10kb) Multiome | 199 | |
| chr21:17,512,112–17,514,078 | 100.0 kb | Distal (>10kb) Multiome | 821 | |
| chr21:17,611,431–17,613,632 | 64 bp | At TSS Multiome | 814 | |
| chr21:17,818,374–17,820,345 | 206.6 kb | Distal (>10kb) Multiome | 840 |
Genomic view of the BTG3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.