Transcription factors with Perturb-seq knockdown data for BTBD19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BTBD19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BTBD19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:44,799,477–44,801,039 | 7.5 kb | Proximal (<10kb) | 1017 | |
| chr1:44,807,115–44,808,920 | at TSS | At TSS | 987 | |
| chr1:44,812,965–44,814,105 | 4.4 kb | Proximal (<10kb) | 349 | |
| chr1:44,815,061–44,815,277 | 6.5 kb | Proximal (<10kb) | 94 | |
| chr1:44,818,937–44,820,693 | 5.4 kb | Proximal (<10kb) | 1101 |
Genomic view of the BTBD19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.