This gene encodes a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The encoded protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators. This protein binds to the catalytic MYST domains of the MOZ and MORF proteins and may play a role in stimulating acetyltransferase and transcriptional activity of the complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for BRPF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BRPF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BRPF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:9,499,948–9,500,976 | 231.1 kb | Distal (>10kb) Multiome HiCAR | 320 | |
| chr3:9,552,048–9,552,879 | 179.3 kb | Distal (>10kb) Multiome | 372 | |
| chr3:9,553,391–9,554,161 | 177.9 kb | Distal (>10kb) Multiome | 128 | |
| chr3:9,649,068–9,649,746 | 82.4 kb | Distal (>10kb) Multiome | 793 | |
| chr3:9,703,572–9,705,701 | 26.6 kb | Distal (>10kb) Multiome | 664 | |
| chr3:9,727,013–9,727,518 | 4.5 kb | Proximal (<10kb) Multiome | 264 | |
| chr3:9,730,724–9,732,470 | 403 bp | At TSS Multiome | 934 | |
| chr3:9,749,252–9,750,525 | 18.2 kb | Distal (>10kb) Multiome | 873 | |
| chr3:9,769,503–9,770,124 | 38.2 kb | Distal (>10kb) Multiome | 504 | |
| chr3:9,792,176–9,793,536 | 61.1 kb | Distal (>10kb) Multiome | 915 | |
| chr3:9,809,609–9,810,744 | 78.4 kb | Distal (>10kb) Multiome | 437 | |
| chr3:9,843,116–9,844,397 | 112.3 kb | Distal (>10kb) Multiome | 787 | |
| chr3:9,862,465–9,863,231 | 131.1 kb | Distal (>10kb) Multiome | 581 | |
| chr3:9,890,247–9,891,058 | 158.9 kb | Distal (>10kb) Multiome | 969 | |
| chr3:9,902,504–9,903,128 | 171.1 kb | Distal (>10kb) Multiome | 396 | |
| chr3:9,914,983–9,916,160 | 183.5 kb | Distal (>10kb) Multiome | 668 | |
| chr3:9,916,644–9,917,412 | 185.4 kb | Distal (>10kb) Multiome | 519 | |
| chr3:9,932,470–9,934,327 | 201.1 kb | Distal (>10kb) Multiome | 1035 | |
| chr3:9,946,152–9,947,739 | 214.9 kb | Distal (>10kb) Multiome | 898 | |
| chr3:9,951,898–9,952,503 | 220.6 kb | Distal (>10kb) Multiome | 484 | |
| chr3:9,986,547–9,987,409 | 255.2 kb | Distal (>10kb) Multiome | 907 | |
| chr3:10,008,678–10,009,458 | 277.4 kb | Distal (>10kb) Multiome | 240 | |
| chr3:10,010,580–10,011,700 | 279.5 kb | Distal (>10kb) Multiome | 540 | |
| chr3:10,025,904–10,026,762 | 294.6 kb | Distal (>10kb) Multiome | 871 |
Genomic view of the BRPF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.