The product of this gene in involved in maintenance of genome stability. It is involved in double-strand break repair pathways during mitotic and meiotic homologous recombination and functions in protecting DNA replication forks. The encoded protein contains sites for interactions with PALB2 and EMSY and an N-terminal DNA binding domain. It also contains a RAD51 binding domain with multiple components. It has multiple BRC repeats, an alpha helix domain, oligonucleotide binding folds, and a tower-like domain. It has a nuclear localization signal and a phosphorylation site for cyclin-dependent kinase. The C-terminus of the protein can bind single-stranded and double-stranded DNA. The product of this gene interacts with multiple proteins, including RAD51. It is involved in recruiting RAD51 filaments to DNA double-strand break sites and also in cytoplasmic division. It also acts as a tumor suppressor. Mutations in this gene or decreased expression have been implicated in multiple tumor types, including breast, ovarian, pancreatic, prostate and other cancers. [provided by RefSeq, May 2026]
Transcription factors with Perturb-seq knockdown data for BRCA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BRCA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BRCA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:32,030,849–32,031,840 | 284.1 kb | Distal (>10kb) Multiome | 668 | |
| chr13:32,310,188–32,310,578 | 4.9 kb | Proximal (<10kb) | 133 | |
| chr13:32,314,935–32,316,400 | 81 bp | At TSS Multiome | 896 | |
| chr13:32,409,564–32,410,449 | 94.4 kb | Distal (>10kb) Multiome | 262 | |
| chr13:32,426,853–32,428,509 | 111.9 kb | Distal (>10kb) Multiome | 737 | |
| chr13:32,537,977–32,539,319 | 223.4 kb | Distal (>10kb) Multiome | 749 | |
| chr13:32,585,638–32,587,422 | 270.9 kb | Distal (>10kb) Multiome | 786 |
Genomic view of the BRCA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.