2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for BPGM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BPGM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BPGM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:134,432,345–134,433,248 | 214.0 kb | Distal (>10kb) Multiome | 622 | |
| chr7:134,458,208–134,459,715 | 187.7 kb | Distal (>10kb) Multiome | 797 | |
| chr7:134,547,422–134,548,048 | 99.2 kb | Distal (>10kb) Multiome | 442 | |
| chr7:134,646,328–134,647,406 | 79 bp | At TSS Multiome | 748 | |
| chr7:134,779,110–134,780,363 | 132.7 kb | Distal (>10kb) Multiome | 408 | |
| chr7:134,890,877–134,892,305 | 244.7 kb | Distal (>10kb) Multiome | 673 |
Genomic view of the BPGM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.