The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Transcription factors with Perturb-seq knockdown data for BOC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BOC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BOC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:112,990,506–112,991,646 | 220.4 kb | Distal (>10kb) Multiome | 925 | |
| chr3:113,018,819–113,020,010 | 191.9 kb | Distal (>10kb) Multiome | 965 | |
| chr3:113,210,367–113,212,837 | 855 bp | At TSS Multiome | 482 | |
| chr3:113,240,837–113,244,224 | 30.3 kb | Distal (>10kb) Multiome | 545 | |
| chr3:113,441,051–113,442,064 | 230.0 kb | Distal (>10kb) Multiome | 198 |
Genomic view of the BOC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.