The protein encoded by this gene interacts with several other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for BNIPL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BNIPL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BNIPL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:150,875,863–150,877,222 | 159.9 kb | Distal (>10kb) Multiome | 912 | |
| chr1:150,925,543–150,926,754 | 110.2 kb | Distal (>10kb) Multiome | 813 | |
| chr1:150,973,876–150,975,458 | 61.7 kb | Distal (>10kb) Multiome | 590 | |
| chr1:150,979,331–150,979,990 | 57.0 kb | Distal (>10kb) Multiome | 562 | |
| chr1:150,981,212–150,981,672 | 55.2 kb | Distal (>10kb) Multiome | 379 | |
| chr1:151,006,389–151,007,024 | 29.8 kb | Distal (>10kb) Multiome | 496 | |
| chr1:151,008,116–151,008,852 | 28.1 kb | Distal (>10kb) Multiome | 763 | |
| chr1:151,047,405–151,048,764 | 12.0 kb | Distal (>10kb) Multiome | 714 | |
| chr1:151,059,187–151,059,842 | 23.0 kb | Distal (>10kb) Multiome | 821 | |
| chr1:151,060,204–151,060,723 | 23.9 kb | Distal (>10kb) Multiome | 346 | |
| chr1:151,070,369–151,071,463 | 34.5 kb | Distal (>10kb) Multiome | 835 | |
| chr1:151,131,105–151,132,256 | 94.8 kb | Distal (>10kb) Multiome | 247 | |
| chr1:151,145,115–151,147,333 | 110.2 kb | Distal (>10kb) Multiome | 709 | |
| chr1:151,165,133–151,166,350 | 129.2 kb | Distal (>10kb) Multiome | 940 | |
| chr1:151,189,687–151,190,378 | 153.6 kb | Distal (>10kb) Multiome | 875 | |
| chr1:151,198,185–151,199,073 | 162.0 kb | Distal (>10kb) Multiome | 721 | |
| chr1:151,254,421–151,255,083 | 218.2 kb | Distal (>10kb) Multiome | 770 | |
| chr1:151,281,008–151,283,557 | 245.5 kb | Distal (>10kb) Multiome | 1121 | |
| chr1:151,327,019–151,328,343 | 291.1 kb | Distal (>10kb) Multiome | 719 |
Genomic view of the BNIPL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.