This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for BNIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BNIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BNIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:172,958,380–172,959,872 | 185.5 kb | Distal (>10kb) Multiome | 868 | |
| chr5:172,983,384–172,984,597 | 160.8 kb | Distal (>10kb) Multiome HiCAR | 848 | |
| chr5:173,055,699–173,057,854 | 87.2 kb | Distal (>10kb) Multiome | 1049 | |
| chr5:173,144,311–173,145,555 | 243 bp | At TSS Multiome | 967 | |
| chr5:173,234,580–173,235,384 | 90.5 kb | Distal (>10kb) Multiome | 307 | |
| chr5:173,283,642–173,284,193 | 139.4 kb | Distal (>10kb) Multiome | 911 | |
| chr5:173,327,090–173,330,477 | 185.3 kb | Distal (>10kb) Multiome | 1064 |
Genomic view of the BNIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.