This locus represents naturally occurring readthrough transcription between the neighboring BMS1P4 (BMS1, ribosome biogenesis factor pseudogene 4) and AGAP5 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 5) genes on chromosome 10. The readthrough transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Jan 2019]
Transcription factors with Perturb-seq knockdown data for BMS1P4-AGAP5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BMS1P4-AGAP5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BMS1P4-AGAP5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:73,730,165–73,730,854 | at TSS | At TSS | 823 |
Genomic view of the BMS1P4-AGAP5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.