This gene likely encodes a ribosome assembly protein. A similar protein in yeast functions in 35S-rRNA processing, which includes a series of cleavage steps critical for formation of 40S ribosomes. Related pseudogenes exist on chromosomes 2, 9, 10, 15, 16, and 22.[provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for BMS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BMS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BMS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:42,551,804–42,553,654 | 229.9 kb | Distal (>10kb) Multiome | 691 | |
| chr10:42,637,674–42,639,023 | 144.4 kb | Distal (>10kb) Multiome | 972 | |
| chr10:42,752,966–42,756,016 | 29.5 kb | Distal (>10kb) Multiome | 466 | |
| chr10:42,782,066–42,783,465 | 57 bp | At TSS Multiome | 1124 | |
| chr10:42,866,108–42,867,222 | 84.0 kb | Distal (>10kb) Multiome | 204 | |
| chr10:42,932,398–42,934,239 | 150.1 kb | Distal (>10kb) Multiome | 252 | |
| chr10:42,951,596–42,953,009 | 169.6 kb | Distal (>10kb) Multiome | 263 | |
| chr10:43,026,131–43,027,199 | 244.0 kb | Distal (>10kb) Multiome | 308 | |
| chr10:43,076,256–43,078,068 | 294.2 kb | Distal (>10kb) Multiome | 337 |
Genomic view of the BMS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.