Transcription factors with Perturb-seq knockdown data for BLTP3B-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BLTP3B-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BLTP3B-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:100,141,965–100,143,502 | at TSS | At TSS | 848 | |
| chr12:100,146,627–100,146,912 | 3.6 kb | Proximal (<10kb) | 12 | |
| chr12:100,147,014–100,147,498 | 4.0 kb | Proximal (<10kb) | 10 | |
| chr12:100,151,817–100,152,287 | 8.8 kb | Proximal (<10kb) | 15 |
Genomic view of the BLTP3B-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.