Enables transcription regulator activator activity. Involved in positive regulation of DNA-templated transcription. Located in nucleus. Part of SWI/SNF complex. Implicated in Coffin-Siris syndrome 12. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BICRA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BICRA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BICRA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:47,348,695–47,349,758 | 259.9 kb | Distal (>10kb) Multiome | 766 | |
| chr19:47,406,825–47,407,408 | 201.8 kb | Distal (>10kb) Multiome | 333 | |
| chr19:47,427,132–47,428,809 | 181.9 kb | Distal (>10kb) Multiome | 506 | |
| chr19:47,429,865–47,430,531 | 178.8 kb | Distal (>10kb) Multiome | 438 | |
| chr19:47,447,043–47,448,262 | 161.5 kb | Distal (>10kb) Multiome | 510 | |
| chr19:47,471,631–47,472,340 | 137.1 kb | Distal (>10kb) Multiome | 500 | |
| chr19:47,479,940–47,480,772 | 129.0 kb | Distal (>10kb) Multiome | 147 | |
| chr19:47,483,636–47,484,543 | 125.0 kb | Distal (>10kb) Multiome | 841 | |
| chr19:47,514,152–47,515,901 | 93.8 kb | Distal (>10kb) Multiome | 895 | |
| chr19:47,600,223–47,600,983 | 8.6 kb | Proximal (<10kb) Multiome | 807 | |
| chr19:47,607,980–47,609,479 | 321 bp | At TSS Multiome | 832 | |
| chr19:47,610,118–47,610,553 | 985 bp | At TSS | 468 | |
| chr19:47,613,212–47,613,473 | 4.1 kb | Proximal (<10kb) | 97 | |
| chr19:47,647,803–47,648,987 | 39.3 kb | Distal (>10kb) Multiome | 693 | |
| chr19:47,697,956–47,698,391 | 89.1 kb | Distal (>10kb) Multiome | 453 | |
| chr19:47,729,949–47,730,505 | 121.1 kb | Distal (>10kb) Multiome | 425 | |
| chr19:47,743,369–47,743,911 | 134.6 kb | Distal (>10kb) Multiome | 929 | |
| chr19:47,745,136–47,745,915 | 136.4 kb | Distal (>10kb) Multiome | 784 | |
| chr19:47,765,762–47,766,380 | 156.9 kb | Distal (>10kb) Multiome | 296 | |
| chr19:47,770,120–47,770,789 | 161.3 kb | Distal (>10kb) Multiome | 127 | |
| chr19:47,778,102–47,779,241 | 169.4 kb | Distal (>10kb) Multiome | 845 | |
| chr19:47,788,509–47,789,220 | 179.6 kb | Distal (>10kb) Multiome | 365 | |
| chr19:47,790,277–47,790,794 | 181.4 kb | Distal (>10kb) Multiome | 275 | |
| chr19:47,848,678–47,850,092 | 240.8 kb | Distal (>10kb) Multiome | 398 | |
| chr19:47,863,487–47,864,048 | 254.6 kb | Distal (>10kb) Multiome | 384 | |
| chr19:47,891,593–47,892,745 | 283.2 kb | Distal (>10kb) Multiome | 522 |
Genomic view of the BICRA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.