Predicted to enable dynactin binding activity and small GTPase binding activity. Predicted to be involved in Golgi to secretory granule transport; neuron projection development; and vesicle transport along microtubule. Predicted to be located in centrosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BICDL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BICDL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BICDL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:118,103,306–118,104,597 | 1885.2 kb | Distal (>10kb) Multiome HiCAR | 730 | |
| chr12:119,804,112–119,804,641 | 184.8 kb | Distal (>10kb) Multiome | 387 | |
| chr12:119,876,730–119,877,837 | 111.9 kb | Distal (>10kb) Multiome | 609 | |
| chr12:119,988,471–119,990,364 | 304 bp | At TSS Multiome | 892 | |
| chr12:120,086,807–120,087,619 | 98.0 kb | Distal (>10kb) Multiome | 957 | |
| chr12:120,093,667–120,094,287 | 104.8 kb | Distal (>10kb) Multiome | 172 | |
| chr12:120,116,125–120,117,765 | 127.6 kb | Distal (>10kb) Multiome | 903 | |
| chr12:120,194,328–120,196,208 | 205.6 kb | Distal (>10kb) Multiome | 1032 | |
| chr12:120,200,671–120,201,921 | 212.0 kb | Distal (>10kb) Multiome | 1006 | |
| chr12:120,228,170–120,231,900 | 239.5 kb | Distal (>10kb) Multiome | 1050 | |
| chr12:120,265,150–120,266,362 | 276.6 kb | Distal (>10kb) Multiome | 617 |
Genomic view of the BICDL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.