Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of DNA-binding transcription factor activity and positive regulation of transcription by RNA polymerase II. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for BEX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BEX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BEX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:102,768,555–102,769,457 | 295.1 kb | Distal (>10kb) Multiome | 420 | |
| chrX:103,063,487–103,064,433 | at TSS | At TSS | 227 | |
| chrX:103,101,365–103,102,296 | 37.7 kb | Distal (>10kb) Multiome | 252 | |
| chrX:103,214,792–103,216,027 | 150.9 kb | Distal (>10kb) Multiome | 433 | |
| chrX:103,254,119–103,255,539 | 191.2 kb | Distal (>10kb) Multiome | 553 | |
| chrX:103,310,557–103,311,346 | 246.8 kb | Distal (>10kb) Multiome | 289 |
Genomic view of the BEX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.