Predicted to enable DNA binding activity. Involved in negative regulation of DNA-templated transcription. Predicted to be located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BEND5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BEND5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BEND5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:48,498,158–48,499,133 | 278.4 kb | Distal (>10kb) Multiome | 244 | |
| chr1:48,499,218–48,501,656 | 276.0 kb | Distal (>10kb) Multiome | 297 | |
| chr1:48,530,436–48,531,227 | 246.0 kb | Distal (>10kb) Multiome | 414 | |
| chr1:48,775,779–48,777,993 | 33 bp | At TSS Multiome | 359 | |
| chr1:50,332,774–50,334,090 | 1556.4 kb | Distal (>10kb) Multiome HiCAR | 583 |
Genomic view of the BEND5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.