Predicted to enable kinase activity. Predicted to be involved in evoked excitatory postsynaptic potential and regulation of postsynaptic neurotransmitter receptor activity. Predicted to be located in dendrite; nucleus; and presynapse. Predicted to be active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BEGAIN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BEGAIN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BEGAIN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:100,304,634–100,307,624 | 280.8 kb | Distal (>10kb) Multiome | 725 | |
| chr14:100,318,097–100,318,705 | 269.0 kb | Distal (>10kb) Multiome | 363 | |
| chr14:100,375,470–100,376,763 | 211.1 kb | Distal (>10kb) Multiome | 889 | |
| chr14:100,546,059–100,547,136 | 41.0 kb | Distal (>10kb) Multiome | 334 | |
| chr14:100,586,725–100,587,571 | at TSS | At TSS | 365 | |
| chr14:100,726,581–100,727,306 | 139.5 kb | Distal (>10kb) Multiome | 303 |
Genomic view of the BEGAIN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.