This gene encodes an enzyme which oxidizes carotenoids such as beta-carotene during the biosynthesis of vitamin A. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for BCO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BCO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BCO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:111,878,459–111,879,798 | 296.4 kb | Distal (>10kb) Multiome | 970 | |
| chr11:111,918,534–111,919,259 | 256.6 kb | Distal (>10kb) Multiome | 468 | |
| chr11:111,926,372–111,927,689 | 248.4 kb | Distal (>10kb) Multiome | 767 | |
| chr11:111,936,752–111,938,016 | 238.2 kb | Distal (>10kb) Multiome | 671 | |
| chr11:111,960,703–111,961,374 | 214.5 kb | Distal (>10kb) Multiome | 192 | |
| chr11:111,976,357–111,978,029 | 198.3 kb | Distal (>10kb) Multiome | 293 | |
| chr11:111,982,641–111,983,482 | 192.2 kb | Distal (>10kb) Multiome | 290 | |
| chr11:112,024,495–112,025,893 | 150.4 kb | Distal (>10kb) Multiome | 1024 | |
| chr11:112,073,749–112,074,754 | 101.3 kb | Distal (>10kb) Multiome | 828 | |
| chr11:112,086,268–112,087,320 | 88.7 kb | Distal (>10kb) Multiome | 883 | |
| chr11:112,175,165–112,175,718 | at TSS | At TSS | 306 | |
| chr11:112,225,928–112,226,959 | 51.0 kb | Distal (>10kb) Multiome | 809 | |
| chr11:112,289,677–112,290,832 | 114.7 kb | Distal (>10kb) Multiome | 568 |
Genomic view of the BCO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.