Enables beta-catenin binding activity. Involved in several processes, including negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of epithelial to mesenchymal transition; and positive regulation of transcription by RNA polymerase II. Located in fibrillar center and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BCL9L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BCL9L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BCL9L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:118,634,418–118,635,567 | 290.9 kb | Distal (>10kb) Multiome | 475 | |
| chr11:118,659,166–118,660,029 | 266.3 kb | Distal (>10kb) Multiome HiCAR | 459 | |
| chr11:118,689,268–118,690,813 | 235.8 kb | Distal (>10kb) Multiome HiCAR | 804 | |
| chr11:118,714,768–118,715,435 | 211.1 kb | Distal (>10kb) Multiome HiCAR | 87 | |
| chr11:118,715,577–118,717,605 | 208.7 kb | Distal (>10kb) Multiome HiCAR | 445 | |
| chr11:118,789,603–118,790,362 | 136.1 kb | Distal (>10kb) Multiome | 293 | |
| chr11:118,790,448–118,793,117 | 133.0 kb | Distal (>10kb) Multiome | 958 | |
| chr11:118,907,074–118,907,685 | 18.6 kb | Distal (>10kb) Multiome HiCAR | 491 | |
| chr11:118,909,181–118,909,816 | 16.6 kb | Distal (>10kb) Multiome HiCAR | 326 | |
| chr11:118,909,976–118,911,609 | 15.3 kb | Distal (>10kb) Multiome | 652 | |
| chr11:118,911,717–118,912,963 | 13.7 kb | Distal (>10kb) Multiome | 689 | |
| chr11:118,916,429–118,917,335 | 9.0 kb | Proximal (<10kb) Multiome | 355 | |
| chr11:118,917,640–118,918,851 | 7.5 kb | Proximal (<10kb) Multiome | 522 | |
| chr11:118,919,145–118,920,144 | 5.8 kb | Proximal (<10kb) | 546 | |
| chr11:118,922,051–118,922,432 | 3.5 kb | Proximal (<10kb) | 387 | |
| chr11:118,924,640–118,925,033 | 892 bp | At TSS | 347 | |
| chr11:118,925,703–118,926,356 | 108 bp | At TSS Multiome | 595 | |
| chr11:118,927,947–118,930,852 | 3.5 kb | Proximal (<10kb) Multiome | 892 | |
| chr11:118,997,538–118,998,797 | 72.2 kb | Distal (>10kb) Multiome | 798 | |
| chr11:119,018,081–119,019,265 | 92.6 kb | Distal (>10kb) Multiome | 897 | |
| chr11:119,029,885–119,031,330 | 105.0 kb | Distal (>10kb) Multiome | 876 | |
| chr11:119,056,436–119,057,778 | 131.4 kb | Distal (>10kb) Multiome | 815 | |
| chr11:119,067,446–119,068,100 | 141.8 kb | Distal (>10kb) Multiome | 762 | |
| chr11:119,084,563–119,085,756 | 159.1 kb | Distal (>10kb) Multiome | 846 | |
| chr11:119,093,969–119,096,070 | 169.6 kb | Distal (>10kb) Multiome | 1046 | |
| chr11:119,101,351–119,102,791 | 176.2 kb | Distal (>10kb) Multiome | 871 | |
| chr11:119,106,906–119,107,993 | 181.4 kb | Distal (>10kb) Multiome | 650 | |
| chr11:119,120,857–119,122,037 | 195.5 kb | Distal (>10kb) Multiome | 787 | |
| chr11:119,144,795–119,145,355 | 219.2 kb | Distal (>10kb) Multiome | 230 | |
| chr11:119,148,816–119,149,933 | 223.7 kb | Distal (>10kb) Multiome | 262 | |
| chr11:119,168,601–119,169,645 | 243.0 kb | Distal (>10kb) Multiome | 794 | |
| chr11:119,205,241–119,207,150 | 280.2 kb | Distal (>10kb) Multiome | 695 |
Genomic view of the BCL9L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.