This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. This gene is highly conserved from C. elegans to human. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2010]
Transcription factors with Perturb-seq knockdown data for BCL7B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BCL7B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BCL7B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:73,324,142–73,324,594 | 233.4 kb | Distal (>10kb) Multiome | 226 | |
| chr7:73,423,745–73,424,470 | 133.5 kb | Distal (>10kb) Multiome | 298 | |
| chr7:73,433,411–73,434,685 | 123.9 kb | Distal (>10kb) Multiome | 614 | |
| chr7:73,521,449–73,522,945 | 35.2 kb | Distal (>10kb) Multiome | 977 | |
| chr7:73,556,852–73,558,145 | 345 bp | At TSS Multiome | 1080 | |
| chr7:73,564,409–73,564,632 | 7.2 kb | Proximal (<10kb) | 131 | |
| chr7:73,578,111–73,579,357 | 21.1 kb | Distal (>10kb) Multiome | 765 | |
| chr7:73,612,552–73,613,365 | 55.3 kb | Distal (>10kb) Multiome | 733 | |
| chr7:73,622,785–73,623,555 | 65.4 kb | Distal (>10kb) Multiome | 659 | |
| chr7:73,623,956–73,624,915 | 66.9 kb | Distal (>10kb) Multiome | 652 | |
| chr7:73,647,765–73,648,318 | 90.3 kb | Distal (>10kb) Multiome | 506 | |
| chr7:73,667,449–73,668,409 | 110.1 kb | Distal (>10kb) Multiome | 678 | |
| chr7:73,682,807–73,684,039 | 125.8 kb | Distal (>10kb) Multiome | 803 | |
| chr7:73,703,674–73,704,431 | 146.4 kb | Distal (>10kb) Multiome | 226 | |
| chr7:73,719,255–73,720,191 | 162.0 kb | Distal (>10kb) Multiome | 478 | |
| chr7:73,734,760–73,735,432 | 177.2 kb | Distal (>10kb) Multiome | 592 | |
| chr7:73,738,048–73,739,612 | 181.3 kb | Distal (>10kb) Multiome | 949 | |
| chr7:73,741,460–73,743,811 | 185.4 kb | Distal (>10kb) Multiome | 604 | |
| chr7:73,769,598–73,771,029 | 212.8 kb | Distal (>10kb) Multiome | 496 | |
| chr7:73,831,659–73,832,518 | 274.6 kb | Distal (>10kb) Multiome | 447 | |
| chr7:73,841,730–73,843,136 | 284.8 kb | Distal (>10kb) Multiome | 575 |
Genomic view of the BCL7B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.