This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for BCL7A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BCL7A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BCL7A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:121,792,642–121,795,650 | 227.9 kb | Distal (>10kb) Multiome | 1009 | |
| chr12:121,797,071–121,801,369 | 223.4 kb | Distal (>10kb) Multiome | 1126 | |
| chr12:121,802,658–121,804,393 | 218.9 kb | Distal (>10kb) Multiome | 825 | |
| chr12:121,812,380–121,813,114 | 209.5 kb | Distal (>10kb) Multiome | 458 | |
| chr12:121,839,137–121,840,260 | 182.3 kb | Distal (>10kb) Multiome | 564 | |
| chr12:121,888,344–121,889,335 | 133.2 kb | Distal (>10kb) Multiome | 1141 | |
| chr12:121,918,184–121,919,001 | 103.4 kb | Distal (>10kb) Multiome | 407 | |
| chr12:122,021,348–122,022,698 | 8 bp | At TSS Multiome | 537 | |
| chr12:122,031,497–122,031,887 | 9.5 kb | Proximal (<10kb) | 148 | |
| chr12:122,063,787–122,064,537 | 42.2 kb | Distal (>10kb) Multiome | 742 | |
| chr12:122,064,878–122,065,312 | 43.3 kb | Distal (>10kb) Multiome | 355 | |
| chr12:122,078,081–122,079,394 | 56.7 kb | Distal (>10kb) Multiome | 952 | |
| chr12:122,097,641–122,098,611 | 76.1 kb | Distal (>10kb) Multiome | 462 | |
| chr12:122,155,564–122,156,340 | 134.0 kb | Distal (>10kb) Multiome | 197 | |
| chr12:122,182,856–122,183,527 | 161.2 kb | Distal (>10kb) Multiome | 228 | |
| chr12:122,203,186–122,204,669 | 181.7 kb | Distal (>10kb) Multiome | 500 | |
| chr12:122,225,485–122,227,116 | 204.2 kb | Distal (>10kb) Multiome | 1019 | |
| chr12:122,265,933–122,267,109 | 244.6 kb | Distal (>10kb) Multiome | 1060 |
Genomic view of the BCL7A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.