This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for BCL10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BCL10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BCL10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:84,996,442–84,998,604 | 279.5 kb | Distal (>10kb) Multiome | 490 | |
| chr1:85,047,243–85,049,064 | 228.3 kb | Distal (>10kb) Multiome | 533 | |
| chr1:85,061,692–85,062,785 | 214.4 kb | Distal (>10kb) Multiome | 384 | |
| chr1:85,200,160–85,202,231 | 75.6 kb | Distal (>10kb) Multiome | 895 | |
| chr1:85,224,822–85,225,910 | 51.4 kb | Distal (>10kb) Multiome | 499 | |
| chr1:85,258,924–85,260,262 | 16.9 kb | Distal (>10kb) Multiome | 782 | |
| chr1:85,275,751–85,277,437 | 8 bp | At TSS Multiome | 868 | |
| chr1:85,282,492–85,282,764 | 5.9 kb | Proximal (<10kb) | 84 | |
| chr1:85,283,608–85,283,817 | 7.0 kb | Proximal (<10kb) | 159 | |
| chr1:85,307,937–85,308,862 | 31.6 kb | Distal (>10kb) Multiome | 554 | |
| chr1:85,464,074–85,465,652 | 188.4 kb | Distal (>10kb) Multiome | 747 | |
| chr1:85,576,283–85,578,303 | 300.4 kb | Distal (>10kb) Multiome | 711 | |
| chr1:86,755,319–86,756,660 | 1479.4 kb | Distal (>10kb) Multiome HiCAR | 183 |
Genomic view of the BCL10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.