Transcription factors with Perturb-seq knockdown data for BAIAP2-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BAIAP2-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BAIAP2-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:80,833,089–80,833,581 | 201.5 kb | Distal (>10kb) Multiome | 572 | |
| chr17:80,981,166–80,981,777 | 53.4 kb | Distal (>10kb) Multiome | 249 | |
| chr17:80,991,699–80,992,263 | 42.9 kb | Distal (>10kb) Multiome | 639 | |
| chr17:81,033,927–81,036,743 | 123 bp | At TSS Multiome | 822 | |
| chr17:81,101,596–81,102,059 | 67.0 kb | Distal (>10kb) Multiome | 815 | |
| chr17:81,222,360–81,223,690 | 188.3 kb | Distal (>10kb) Multiome | 861 | |
| chr17:81,238,602–81,239,760 | 204.3 kb | Distal (>10kb) Multiome | 811 | |
| chr17:81,295,024–81,295,658 | 260.4 kb | Distal (>10kb) Multiome | 832 |
Genomic view of the BAIAP2-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.