The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for BAG5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BAG5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BAG5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:103,333,053–103,335,386 | 228.6 kb | Distal (>10kb) Multiome | 1004 | |
| chr14:103,384,755–103,386,021 | 177.3 kb | Distal (>10kb) Multiome | 863 | |
| chr14:103,456,058–103,456,564 | 106.3 kb | Distal (>10kb) Multiome | 49 | |
| chr14:103,518,427–103,519,043 | 43.9 kb | Distal (>10kb) Multiome | 404 | |
| chr14:103,520,443–103,523,552 | 39.8 kb | Distal (>10kb) Multiome | 756 | |
| chr14:103,528,671–103,529,619 | 33.5 kb | Distal (>10kb) Multiome | 726 | |
| chr14:103,561,982–103,563,356 | 143 bp | At TSS Multiome | 781 | |
| chr14:103,628,110–103,630,126 | 66.5 kb | Distal (>10kb) Multiome | 909 | |
| chr14:103,715,029–103,716,504 | 153.0 kb | Distal (>10kb) Multiome | 709 | |
| chr14:103,846,809–103,848,686 | 285.0 kb | Distal (>10kb) Multiome | 711 | |
| chr14:103,855,145–103,855,758 | 292.9 kb | Distal (>10kb) Multiome | 418 |
Genomic view of the BAG5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.