Transcription factors with Perturb-seq knockdown data for BAALC-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BAALC-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BAALC-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:103,020,472–103,021,647 | 277.7 kb | Distal (>10kb) Multiome | 842 | |
| chr8:103,298,291–103,299,527 | 160 bp | At TSS Multiome | 649 | |
| chr8:103,370,990–103,372,400 | 72.7 kb | Distal (>10kb) Multiome | 619 | |
| chr8:103,414,336–103,415,724 | 116.4 kb | Distal (>10kb) Multiome | 1010 | |
| chr8:103,498,473–103,502,003 | 202.9 kb | Distal (>10kb) Multiome | 670 |
Genomic view of the BAALC-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.